Applicability of ToF-SIMS for monitoring compositional changes in bone in a long-term animal model.


Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a well-established technique in material sciences but has not yet been widely explored for implementation in life sciences. Here, we demonstrate the applicability and advantages of ToF-SIMS analysis for the study of minerals and biomolecules in osseous tissue. The locally resolved analysis of… (More)
DOI: 10.1098/rsif.2013.0332


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