Apple polyphenols extend the mean lifespan of Drosophila melanogaster.

  title={Apple polyphenols extend the mean lifespan of Drosophila melanogaster.},
  author={Cheng Peng and Ho Y. Chan and Yu Huang and Hongjian Yu and Zhen-Yu Chen},
  journal={Journal of agricultural and food chemistry},
  volume={59 5},
Apple polyphenols (AP) are an excellent source of dietary antioxidants. The present study investigated the effect of AP on the lifespan of fruit flies and their interaction with gene expressions of superoxide dismutase (SOD), catalase (CAT), methuselah (MTH), Rpn11, and cytochrome c oxidase (CcO) subunits III and VIb. Results showed the mean lifespan was significantly extended by 10% in fruit flies fed the AP diet. This was accompanied by up-regulation of genes SOD1, SOD2, and CAT and down… CONTINUE READING


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Hepatoprotective e ff ects of apple polyphenols on CCl 4 - induced acute liver damage in mice

J. Yang, Y. Li, C. Wu
J . Agric . Food Chem . • 2010

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