Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo.

@article{Graziani2005ApplePE,
  title={Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo.},
  author={Giulia Graziani and Giuseppe D'Argenio and Concetta Tuccillo and Carmelina Loguercio and Alberto Ritieni and Filomena Morisco and Camillo Del Vecchio Blanco and Vincenzo Fogliano and Marco Romano},
  journal={Gut},
  year={2005},
  volume={54 2},
  pages={193-200}
}
BACKGROUND Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS Apple extracts were obtained from freeze dried apple flesh of the "Annurca" variety. Cell damage was induced by incubating MKN 28 cells with xanthine-xanthine oxidase or indomethacin and quantitated by MTT. In vivo gastric… CONTINUE READING
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