Apple juice greatly reduces systemic exposure to atenolol.

@article{Jeon2013AppleJG,
  title={Apple juice greatly reduces systemic exposure to atenolol.},
  author={Hyewon Jeon and I. C. Jang and Seunghwan Lee and Kyoichi Ohashi and Tsutomu Kotegawa and Ichiro Ieiri and Joo Youn Cho and Seo Hyun Yoon and S Shin and Kyung-Sang Yu and Kyoung Soo Lim},
  journal={British journal of clinical pharmacology},
  year={2013},
  volume={75 1},
  pages={172-9}
}
AIM Fruit juice reduces the plasma concentrations of several β-adrenoceptor blockers, likely by inhibiting OATP2B1-mediated intestinal absorption. The aim of this study was to investigate the effects of apple juice on the pharmacokinetics of atenolol. METHODS Twelve healthy Korean volunteers with genotypes of SLCO2B1 c.1457C> T (*1/*1 (n = 6) and *3/*3 (n… CONTINUE READING
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