Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats.

@article{Lee2011AppleFP,
  title={Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats.},
  author={Jin-Hyung Lee and Sushil Chandra Regmi and Jung-Ae Kim and Moo Hwan Cho and Hyungdon Yun and Chang-Soo Lee and Jintae Lee},
  journal={Infection and immunity},
  year={2011},
  volume={79 12},
  pages={
          4819-27
        }
}
Pathogenic biofilms have been associated with persistent infections due to their high resistance to antimicrobial agents, while commensal biofilms often fortify the host's immune system. Hence, controlling biofilm formation of both pathogenic bacteria and commensal bacteria is important in bacterium-related diseases. We investigated the effect of plant flavonoids on biofilm formation of enterohemorrhagic Escherichia coli O157:H7. The antioxidant phloretin, which is abundant in apples, markedly… CONTINUE READING
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