Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity.

@article{Luo2015ApplanatuminAA,
  title={Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity.},
  author={Qi Luo and Lei Di and Wei-Feng Dai and Qing Lu and Yong-Ming Yan and Zhu L. Yang and Rong-Tao Li and Yong-Xian Cheng},
  journal={Organic letters},
  year={2015},
  volume={17 5},
  pages={1110-3}
}
Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-β1-induced human renal… CONTINUE READING