Appetite stimulants in cystic fibrosis: a systematic review.

@article{Chinuck2007AppetiteSI,
  title={Appetite stimulants in cystic fibrosis: a systematic review.},
  author={R. S. Chinuck and Heather M. Fortnum and David R. Baldwin},
  journal={Journal of human nutrition and dietetics : the official journal of the British Dietetic Association},
  year={2007},
  volume={20 6},
  pages={
          526-37
        }
}
  • R. Chinuck, H. Fortnum, D. Baldwin
  • Published 2007
  • Medicine
  • Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
BACKGROUND The use of appetite stimulants in cystic fibrosis (CF) is controversial because of doubts concerning efficacy and side-effects. The aim of the review was to establish whether appetite stimulants should be recommended in CF. MATERIALS AND METHODS Medline, AMED, British Nursing Index, Cinahl, Embase, The Cochrane Library, National Research Register and Google were searched. Unpublished studies, case reports and conference abstracts were sought from experts, including authors of… Expand
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References

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Cyproheptadine is an effective appetite stimulant in cystic fibrosis
TLDR
In conclusion, cyproheptadine hydrochloride appears to be an effective appetite stimulant with minimal side effects in children and adults with CF. Expand
Long‐term trial of cyproheptadine as an appetite stimulant in cystic fibrosis
TLDR
CH appears to be an effective appetite stimulant in CF, and generally maintains its effect over time with an acceptable side‐effect profile. Expand
Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis.
TLDR
Short-term use of megestrol acetate results in significant weight gain and improved pulmonary function in malnourished subjects with CF, and provides the foundation for multiyear, longitudinal trials in a larger number of patients with CF. Expand
Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Megestrol Acetate in Malnourished Children With Cystic Fibrosis
TLDR
Weight, body fat, and lean body mass increased and pulmonary function improved in the children with CF given megestrol acetate, and serum cortisol levels decreased in the MA group. Expand
Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome.
TLDR
MA is an effective and safe treatment for ACS in cancer and AIDS patients, particularly in terms of improvement in appetite and weight gain, and shows significant benefits over dronabinol in improving appetite. Expand
Gut hormones and gastrointestinal motility in children with cystic fibrosis
TLDR
Fasting levels of peptide YY and the postprandial response of all four peptides were significantly increased in those with cystic fibrosis, and altered gut hormone secretion may play a role in the pathophysiology of intestinal dysmotility in patients with cysts fibrosis. Expand
Short-term nutritional supplementation during management of pulmonary exacerbations in cystic fibrosis: a controlled study, including effects of protein turnover.
TLDR
Pulmonary exacerbations in CF have important adverse effects on body-protein metabolism, similar to changes in protein-energy malnutrition and infection, which are reversed by short-term nutritional support, especially in malnourished patients. Expand
Nutrition and survival in cystic fibrosis.
TLDR
The interactions between the lung disease and nutrition are important because nutritional state usually parallels declining lung function and is a predictor of survival and a better understanding of how these two factors relate to each other and influence survival may lead to further gains in outcome for patients. Expand
Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis
TLDR
Four patients with severe cystic fibrosis lung disease, anorexia and weight loss, received Megestrol Acetate, as an appetite stimulant, with significant weight gain in all patients and an increase in their weight for age percentile after 6 months of use. Expand
Nutrition in patients with cystic fibrosis: a European Consensus.
This document is the result of an European Consensus conference which took place in Artimino, Tuscany, Italy, in March 2001 involving 33 experts on nutrition in patients with cystic fibrosis,Expand
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