Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions.

@article{Higashi2007AppearancePO,
  title={Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions.},
  author={Shinji Higashi and Eizo Iseki and Ryoko Yamamoto and Michiko Minegishi and Hiroaki Hino and Koshiro Fujisawa and Takashi Togo and O Katsuse and Hirotake Uchikado and Yoshiko Furukawa and Kenji Kosaka and H. i 24 Arrizabalaga Arai},
  journal={Neuroscience letters},
  year={2007},
  volume={419 3},
  pages={213-8}
}
TAR-DNA-binding protein 43 (TDP-43) was identified as a major component of ubiquitin-positive intracellular inclusions from brains of patients with frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Here, we immunohistochemically investigated the appearance pattern of TDP-43 to compare the distribution of TDP-43-positive structures with that of ubiquitin-positive structures in brains of seven patients with Japanese FTLD-U, five of atypical Pick's disease (aPiD) and… CONTINUE READING

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