Appearance of tubulovesicular structures in experimental Creutzfeldt-Jakob disease and scrapie preceeds the onset of clinical disease

@article{Liberski1990AppearanceOT,
  title={Appearance of tubulovesicular structures in experimental Creutzfeldt-Jakob disease and scrapie preceeds the onset of clinical disease},
  author={Pawel P. Liberski and Richard Yanagihara and Clarence J. Gibbs and D. Carleton Gajdusek},
  journal={Acta Neuropathologica},
  year={1990},
  volume={79},
  pages={349-354}
}
We have consistently observed tubulovesicular structures in brain tissues during the terminal stages of naturally occurring and experimentally induced spongiform encephalopathies, irrespective of the host species and virus strain. In NIH Swiss mice inoculated intracerebrally or intraocularly with the Fujisaki strain of Creutzfeldt-Jakob disease (CJD) virus, tubulovesicular structures, measuring 20–50 nm in diameter, were particularly prominent in dilated, pre-and postsynaptic neuronal processes… CONTINUE READING