Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?

  title={Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness?},
  author={A. -M. van Dam and Madeleine R. Brouns and Simone Louisse and Frank Berkenbosch},
  journal={Brain Research},
Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin
The data suggest that increased production of nitric oxide may play a role in the altered brain functions in rabies‐infected and EAE rats and that increased nitrous oxide production is probably not involved in the non‐specific symptoms of sickness induced by endotoxin.
Brain Perivascular Macrophages Do Not Mediate Interleukin-1-Induced Sickness Behavior in Rats
It is shown that intracerebroventricular administration of an IL-1β-saporin conjugate is an efficient way to target brain perivascular macrophages, and to determine whether these cells are involved in IL- 1β-induced sickness behavior.
Effects of Peripheral Administration of LPS on the Expression of Immunoreactive Interleukin‐1α, β, and Receptor Antagonist in Rat Brain
IL‐lα and IL‐1β production in the brain is induced in the same cell types, whereas IL‐lra is expressed consititutively by a different cell type‐probably neurons.


Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro
Amoeboid microglial cells (brain macrophages) were purified from early post‐natal mouse brain cultures. The percentage of cells stained with an anti‐Mac‐1 antibody was > 95%. Stimulation of these
Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.
Astrocytes may interact with the immune system by elaborating nonspecific factors that modulate lymphocyte proliferation, which may be important in the generation of specific immune responses in the brain, which is considered to be an immunologically privileged organ.
Selective depletion of macrophages prevents pituitary-adrenal activation in response to subpyrogenic, but not to pyrogenic, doses of bacterial endotoxin in rats.
Data demonstrate that activation of the HPAA by a subpyrogenic dose of LPS is macrophage dependent, however, Macrophage-independent mechanisms mediate activation ofThe HPAA in response to a pyrogenic doses of L PS.
Ameboid microglia as effectors of inflammation in the central nervous system
  • D. Giulian
  • Biology, Medicine
    Journal of neuroscience research
  • 1987
Examination of surface morphology, proliferative capacity, and cytochemistry suggests that microglia are a class of brain mononuclear phagocytes distinct from blood monocytes, spleen macrophage, or resident peritoneal macrophages.
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.
Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived and are fully competent to present antigen to lymphocytes in an appropriately restricted manner.
Identity of ED2‐positive perivascular cells in rat brain
This work shows that a group of perivascular cells located within the basal membrane of CNS blood vessels are immunoreactive, and demonstrates considerable heterogeneity in the immunophenotype of resident brain macrophages, which may be part of the immune—nervous system interface.
The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in rat recognized by monoclonal antibodies ED1, ED2 and ED3.
A set of three monoclonal antibodies is described, each of which recognizes cells of the monocyte-macrophage lineage in the rat, with results showing that ED1 recognizes a cytoplasmic antigen in monocytes and in most macrophages, free and fixed.
Functions and mechanisms of interleukin 1 in the brain.
  • N. Rothwell
  • Biology, Psychology
    Trends in pharmacological sciences
  • 1991
Control of brain endothelial permeability.
Comparison of the brain endothelium with the perineurium of peripheral nerve, part of the blood-nerve barrier, suggests that the modulation of brain endothelial permeability seen in pathological situations may give some physiological advantage.
A new technique for studying specificity of immunocytochemical procedures: specificity of serotonin immunostaining.
  • J. Schipper, F. Tilders
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1983
A novel nonbiological model is described that can be used to evaluate the specificity of immunocytochemical procedures and the potency ofvarious substances in solution to inhibit immunostaining of antigen-containing gels can be determined.