Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition.

@article{Dumont2000AppearanceOB,
  title={Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition.},
  author={Patrick Dumont and Laura Balbeur and Jos{\'e} Remacle and Olivier Toussaint},
  journal={Journal of anatomy},
  year={2000},
  volume={197 Pt 4},
  pages={
          529-37
        }
}
Sublethal oxidative stresses increase the proportions of human fibroblasts positive for senescence associated beta-galactosidase activity and accelerate the transition in the fibroblast morphotypes characterising fibroblast ageing. Stimulation of fibroblasts with TNF-alpha or IL-1alpha transiently increases the production of reactive oxygen species (ROS) in human fibroblasts. Here we propose that repeated stimulation of WI-38 fibroblasts with TNF-alpha or IL-1alpha can generate enough ROS to… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Stress, cell senescence and organismal ageing

  • Mechanisms of Ageing and Development
  • 2017
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED