Appearance of LFA-1 in the initial stage of synaptogenesis of developing hippocampal neurons.

@article{Wakabayashi2008AppearanceOL,
  title={Appearance of LFA-1 in the initial stage of synaptogenesis of developing hippocampal neurons.},
  author={Yoshihiro Wakabayashi and Atsushi Tsujimura and Ken-ichi Matsuda and Norio Yoshimura and M D Kinsuke Kawata},
  journal={Archives of histology and cytology},
  year={2008},
  volume={71 1},
  pages={
          23-36
        }
}
In the present study, we found that leucocyte function-associated antigen-1 (LFA-1), and integrin (heterodimer complex of CD11a and CD18), which are abundant in immunological synapse, were expressed in developing hippocampal neurons. The expression of LFA-1 in hippocampal neurons was in the period of synaptogenesis, and synaptogenesis was inhibited by the blocking antibodies of anti-CD11a or anti-CD18 in vitro. Since it is known that LFA-1 has an important role in the immunological response… CONTINUE READING
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