• Biology, Medicine
  • Published in Haematologica 1997

Apparently normal ankyrin content in unsplenectomized hereditary spherocytosis patients with the inactivation of one ankyrin (ANK1) allele.

@article{Giudice1997ApparentlyNA,
  title={Apparently normal ankyrin content in unsplenectomized hereditary spherocytosis patients with the inactivation of one ankyrin (ANK1) allele.},
  author={Emanuele Miraglia del Giudice and Matteo Francese and R Polito and Bruno Nobili and Achille Iolascon and Silverio Perrotta},
  journal={Haematologica},
  year={1997},
  volume={82 3},
  pages={
          332-3
        }
}
The study of erythrocyte membrane protein concentration by polyacrylamide gel electrophoresis (PAGE) is the first step in approaching the primary molecular defect in hereditary spherocytosis (HS). Normal or greater than normal protein 2.1 levels were found in ten unrelated HS patients showing the inactivation of one ankyrin allele. Erythrocyte membranes from the same patients, once splenectomized, showed a homogeneous degree of protein 2.1 reduction. Thus protein 2.1 levels could misleadingly… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

ICSH guidelines for the laboratory diagnosis of nonimmune hereditary red cell membrane disorders.

  • International journal of laboratory hematology
  • 2015
VIEW 1 EXCERPT
CITES RESULTS