Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside.

@article{Rauhala1998ApparentRO,
  title={Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside.},
  author={Pekka Rauhala and Ahmad Khaldi and Kochupurackal Parameswarannayar Mohanakumar and Chuang Chin Chiueh},
  journal={Free radical biology & medicine},
  year={1998},
  volume={24 7-8},
  pages={1065-73}
}
Sodium nitroprusside (disodium nitroferricyanide) has been suggested to cause cytotoxicity through either the release of cyanide and/or nitric oxide. The present study investigated a possible mechanism that after a brief release of nitric oxide, iron moiety of breakdown products of sodium nitroprusside could cause a long lasting oxidative stress, such as hydroxyl radical generation, lipid peroxidation and cytotoxicity. Intranigral administration of sodium nitroprusside (0-16.8 nmol) to rats… CONTINUE READING
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