Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites.

@article{Sprouse1993ApparentRD,
  title={Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites.},
  author={Jeffrey S Sprouse and Donald R McCarty and Mark W. Dudley},
  journal={Brain research},
  year={1993},
  volume={617 1},
  pages={159-62}
}
The binding of [3H]8-OH-DPAT and [3H]paroxetine to 5-HT1A and 5-HT uptake sites (respectively) was examined in membranes prepared from bovine dorsal raphe and hippocampus. KD and Bmax values for [3H]8-OH-DPAT binding were indistinguishable in dorsal raphe nucleus and hippocampus. Competition studies with MDL 73,005EF, a selective 5-HT1A ligand, revealed a high and a low affinity site in the dorsal raphe, but only the high affinity component in hippocampal membranes. The low affinity component… CONTINUE READING

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