Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.

@article{Baranova1997ApparentIO,
  title={Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.},
  author={Natalya N. Baranova and Alexander A. Neyfakh},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 6},
  pages={1396-8}
}
A Streptococcus pneumoniae strain selected for resistance to ethidium bromide demonstrated enhanced energy-dependent efflux of this toxic dye. Both the ethidium resistance and the ethidium efflux could be inhibited by the plant alkaloid reserpine. The ethidium-selected cells demonstrated cross-resistance to the fluoroquinolones norfloxacin and ciprofloxacin; this resistance could also be completely reversed by reserpine. Furthermore, reserpine potentiated the susceptibility of wild-type S… CONTINUE READING

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Emerging fluoroquinolone resistance in Streptococcus agalactiae in South Korea

European Journal of Clinical Microbiology & Infectious Diseases • 2012

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Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

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