Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution.

@article{Sekikawa1995ApparentIA,
  title={Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution.},
  author={Hitoshi Sekikawa and Naomi Yagi and Emil T. Lin and Leslie Z Benet},
  journal={Biological & pharmaceutical bulletin},
  year={1995},
  volume={18 1},
  pages={134-9}
}
The stability of furosemide glucuronide (FG) was investigated in buffer solutions ranging from pH 1 through 10. This glucuronic acid conjugate was the major metabolite of furosemide (F) excreted in human urine. FG, obtained by extraction from human urine, was purified by ion-exchange chromatography. The concentration of FG, acyl migration isomers of FG (FG… CONTINUE READING