Apparent high chloraemia in persons with deep third-degree burns: interference linked to topical treatment.


Thank you for the comment on our article and the emphasis on the changes and effects of burn on the platelets itself. We agree with your statement that the increasing number of bedside kits available is somewhat irritating since they often do not explain the physiological impact. It is not our intention to generally encourage the use of platelet rich plasma (PRP) in burns. On the other side, we feel that several more basic physiological questions should be addressed before a recommendation can be given. Based on this, we do not unconditionally support the use of PRP in patients with burns <10% TBSA. Although a general burn shock is not to be expected, systemically active factors are still released and the influence on platelets is unknown. Burns are complex and unique, so we should be cautious to transfer research findings from other conditions. In general, there is very little data on the effect of burn on platelets [1]. With regard to wound healing and scar formation we also advise caution. Even though the effects of platelet rich plasma on wound healing are not clear yet, van der Veer et al. have recently described the interaction between scar formation and platelets [2]. We should be careful to evaluate new technologies not only by their possible usefulness but also with respect to their efficiency. Using PRP in patients with burns <10%TBSA might not harm but also might not help. As burn surgeons are certainly able to cope with a burn of this extent without PRP, an unproven usefulness is not to be a good rationale for the introduction of PRP. In conclusion, thrombocyte function and effects in burns is certainly is a promising field of research to elucidate another aspect of the pathophysiology of burns. The results will help to evaluate the benefits of platelet rich plasma in this condition.

DOI: 10.1016/j.burns.2009.07.002

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Cite this paper

@article{Chiana2010ApparentHC, title={Apparent high chloraemia in persons with deep third-degree burns: interference linked to topical treatment.}, author={Denis Chian{\'e}a and D{\'e}borah Delaun{\'e} and Corinne Monpeurt and Philippe Vest and Laurent Jean Bargues and Christophe Renard}, journal={Burns : journal of the International Society for Burn Injuries}, year={2010}, volume={36 6}, pages={945-7} }