Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma.

@article{Pope2011ApparentDC,
  title={Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma.},
  author={Whitney B. Pope and Albert Lai and Rajnikant Laxmishanker Mehta and Hak Jin Kim and J Qiao and Jonathan T. Young and Xiaonan Xue and Jonathan G. Goldin and Martin Brown and Phioanh L. Nghiemphu and Anh Van Tran and Timothy F. Cloughesy},
  journal={AJNR. American journal of neuroradiology},
  year={2011},
  volume={32 5},
  pages={882-9}
}
BACKGROUND AND PURPOSE Currently it is difficult to predict tumor response to anti-angiogenic therapy in individual patients. Our aim was to determine if ADC histogram analysis can stratify progression-free and overall survival in patients with newly diagnosed GBM treated "up-front" (ie, before tumor recurrence) with bevacizumab. MATERIALS AND METHODS Up-front bevacizumab-treated and control patients (n = 59 and 62, respectively) with newly diagnosed GBM were analyzed by using an ADC… CONTINUE READING

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