Apparent desensitization of a sigma receptor sub-population in neonatal rat cardiac myocytes by pre-treatment with sigma receptor ligands.

@article{Ela1996ApparentDO,
  title={Apparent desensitization of a sigma receptor sub-population in neonatal rat cardiac myocytes by pre-treatment with sigma receptor ligands.},
  author={Catherine Ela and Yonathan Hasin and Yael Eilam},
  journal={European journal of pharmacology},
  year={1996},
  volume={295 2-3},
  pages={275-80}
}
sigma Receptor ligands induce marked effects on contractility in cardiac myocytes from neonatal and adult rats (Ela et al., 1994, J. Pharmacol. Exp. Ther. 269, 1300-1309; Novakova et al., 1995, Eur. J. Pharmacol. 286, 19-30). Augmentation or attenuation of the contractile amplitude was observed under different experimental conditions. Preincubation of neonatal cardiomyocytes with a sigma receptor ligand ((+)-(3-hydroxyphenyl)-N-(1-propyl)-piperidine ((+)-3PPP), (+)-pentazocine, or haloperidol… CONTINUE READING
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