Apparent activity in high-throughput screening: origins of compound-dependent assay interference.

@article{Thorne2010ApparentAI,
  title={Apparent activity in high-throughput screening: origins of compound-dependent assay interference.},
  author={Natasha Thorne and Douglas S Auld and James Inglese},
  journal={Current opinion in chemical biology},
  year={2010},
  volume={14 3},
  pages={315-24}
}
Expansive compound collections made up of structurally heterogeneous chemicals, the activities of which are largely undefined, present challenging problems for high-throughput screening (HTS). Foremost is differentiating whether the activity for a given compound in an assay is directed against the targeted biology, or is the result of surreptitious compound activity involving the assay detection system. Such compound interference can be especially difficult to identify if it is reproducible and… CONTINUE READING
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