Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

@article{Musset2006ApparentAO,
  title={Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.},
  author={Lise Musset and Bruno Pradines and Daniel Parzy and R{\'e}my Durand and Patricia Bigot and Jacques Le bras},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={57 1},
  pages={110-5}
}
OBJECTIVES We examined the atovaquone in vitro susceptibility and the cytochrome b (cytb) gene polymorphism of African Plasmodium falciparum isolates during the first years of atovaquone/proguanil use. PATIENTS AND METHODS Between 1999 and 2004, we collected blood samples from French P. falciparum-infected patients returning from African countries. Atovaquone susceptibility was determined using an in vitro isotopic test and cytb genotyping was performed by restriction fragment length… CONTINUE READING

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