Apparent Mineralocorticoid Excess Syndrome : An Overview Mario Palermo

Apparent mineralocorticoid excess (AME) syndrome results from defective 11 -hydroxysteroid dehydrogenase type 2 (11 -HSD2). This enzyme is co-expressed with the mineralocorticoid receptor (MR) in the kidney and converts cortisol (F) to its inactive metabolite cortisone (E). Its deficiency allows the unmetabolized cortisol to bind to the MR inducing sodium… CONTINUE READING