App Structure, Dimerization and Processing


APP is a type I transmembrane protein. Its cleavage in the amyloidogenic pathway by βand γ-secretases produces the β-amyloid peptide (Aβ), the major constituent of senile plaques. In addition, the cleavage of the membrane-bound APP C-terminal fragments (CTFs) by γ-secretase releases the AICD (APP Intracellular Cterminal Domain), a soluble intracellular… (More)


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