Apoptotic positive cells in Krabbe brain and induction of apoptosis in rat C6 glial cells by psychosine.

Abstract

Globoid cell leukodystrophy (GLD) is an autosomal recessive disorder of infants, caused by deficient activity of cerebroside-beta-galactosidase resulting in loss of myelin accompanied by loss of oligodendrocytes. The loss of oligodendrocyte population is accompanied by accumulation of psychosine, which is considered as the molecule responsible for the… (More)

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