Apoptotic pathways and therapy resistance in human malignancies.

  title={Apoptotic pathways and therapy resistance in human malignancies.},
  author={Kristina Viktorsson and Rolf Lewensohn and Boris Zhivotovsky},
  journal={Advances in cancer research},
Apoptosis and necrosis are two morphologically distinct forms of cell death that are important for maintaining of cellular homeostasis. Almost all agents can provoke either response when applied to cells; however, the duration of treatment and the dose of the used agents determine which type of death (apoptosis or necrosis) is initiated. The response of tumors to chemo-, radio-, and hormone therapy or to treatment with biologically active agents may depend at least in part on the propensity of… CONTINUE READING