Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation.

@article{Sponne2003ApoptoticNC,
  title={Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation.},
  author={Isabelle Sponne and Alexandre Fifre and B{\'e}atrice Drouet and Christophe Klein and Violette Koziel and Martine Pinçon-Raymond and Jean-Luc Olivier and Jean Chambaz and Thierry Pillot},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 5},
  pages={3437-45}
}
In the present study, we have determined the nature and the kinetics of the cellular events triggered by the exposure of cells to non-fibrillar amyloid-beta peptide (A beta). When cortical neurons were treated with low concentrations of soluble A beta (1-40), an early reactive oxygen species (ROS)-dependent cytoskeleton disruption precedes caspase activation. Indeed, caspase activation and neuronal cell death were prevented by the microtubule-stabilizing drug taxol. A perturbation of the… CONTINUE READING

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