Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons.

@article{Aravind2001ApoptoticMM,
  title={Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons.},
  author={L. Aravind and Vishva M. Dixit and Eugene V. Koonin},
  journal={Science},
  year={2001},
  volume={291 5507},
  pages={1279-84}
}
A comparison of the proteins encoded in the recently (nearly) completed human genome to those from the fly and nematode genomes reveals a major increase in the complexity of the apoptotic molecular machinery in vertebrates, in terms of both the number of proteins involved and their domain architecture. Several components of the apoptotic system are shared by humans and flies, to the exclusion of nematodes, which seems to support the existence of a coelomate clade in animal evolution. A… CONTINUE READING
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