Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome.

  title={Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome.},
  author={Susanne Tan and Lars P Bechmann and Sven Benson and Tiina Dietz and Stefanie Eichner and Susanne Hahn and Onno Eilard Janssen and Harald Lahner and Guido G H Gerken and Klaus Mann and Ali Canbay},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={95 1},
BACKGROUND Polycystic ovary syndrome (PCOS) characterized by chronic anovulation and hyperandrogenism is highly associated with obesity and insulin resistance (IR), two key features of nonalcoholic steatohepatitis (NASH). NASH often leads to cirrhosis, including portal hypertension, liver failure, and hepatocellular carcinoma as long-term complications. The caspase 3-cleaved fragment of cytokeratin 18 (CK18) emerging from ongoing cell death during apoptosis process has been established as a… CONTINUE READING


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