Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls

@inproceedings{Batalla2015ApoptoticMI,
  title={Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls},
  author={Alain Batalla and N Bargall{\'o} and Patricia Gass{\'o} and Oriol Molina and Debora Pareto and Sergi Mas and Josep Maria Roca and Massimo Bernardo and Asunci{\'o}n Lafuente and Eduardo Parellada},
  booktitle={Translational Psychiatry},
  year={2015}
}
Cultured fibroblasts from first-episode schizophrenia patients (FES) have shown increased susceptibility to apoptosis, which may be related to glutamate dysfunction and progressive neuroanatomical changes. Here we determine whether apoptotic markers obtained from cultured fibroblasts in FES and controls correlate with changes in brain glutamate and N-acetylaspartate (NAA) and regional brain volumes. Eleven antipsychotic-naive FES and seven age- and gender-matched controls underwent 3-Tesla… CONTINUE READING
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