Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors.

  title={Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors.},
  author={Toshio Kubota and Koji Fujisaki and Yoshinori Itoh and Takahisa Yano and Toshiaki Sendo and Ryozo Oishi},
  journal={Biochemical pharmacology},
  volume={67 12},
Hepatotoxicity is the major complaint during therapy with lipid-lowering agents such as statins, although the cellular mechanisms underlying the statin-induced liver injury are not fully understood. Using cultured human hepatocytes, we investigated the effects of lipophilic as well as hydrophilic statins on the cell viability. Lipophilic statins, including simvastatin, lovastatin, cerivastatin, fluvastatin and atorvastatin, reduced the viability of hepatocytes as assessed by the mitochondrial… CONTINUE READING


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