Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism

@article{Cai2000ApoptoticGD,
  title={Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism},
  author={Lu Cai and Shali Chen and Terry Evans and Diana Xi Deng and K. C. Mukherjee and Subrata Chakrabarti},
  journal={Urological Research},
  year={2000},
  volume={28},
  pages={342-347}
}
This paper explores the role of endothelins (ETs) in diabetes-induced testicular damage by investigating, in a temporal manner, testes from streptozotocin (STZ)-induced diabetic rats. Testicular and epididymal weights and testicular morphology were assessed. Cell death was evaluated by light microscopy using conventional staining and morphology, and by apoptotic cell staining using the Terminal deoxynucleotidyl transferase-mediated dUTP Nick End-Labeling (TUNEL) technique. Expression of… CONTINUE READING