Apoptotic functions of PDCD10/CCM3, the gene mutated in cerebral cavernous malformation 3.


BACKGROUND AND PURPOSE Mutations in the Programmed Cell Death 10 (PDCD10) gene cause autosomal dominant familial cerebral cavernous malformations (CCM3). To date, little is known about the function of this gene and its role in disease pathogenesis. METHODS We examined the effects of overexpression of wild-type and 2 human disease-causing variants of… (More)
DOI: 10.1161/STROKEAHA.108.527135


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