Apoptotic effects of curcumin on human osteosarcoma U2OS cells.

  title={Apoptotic effects of curcumin on human osteosarcoma U2OS cells.},
  author={Song Zhu Jin and Hong-Guang Xu and Jing-nan Shen and Xu-wu Chen and Hong Wang and Jia-guo Zhou},
  journal={Orthopaedic surgery},
  volume={1 2},
OBJECTIVE  Curcumin, an active ingredient derived from the rhizome of the plant, Curcuma longa, has antioxidant, anti-inflammatory and anti-cancer activities. The aims of this study were to examine whether curcumin can induce apoptosis in an osteosarcoma cell line. METHODS Curcumin-induced apoptosis in human osteosarcoma U2OS cells was investigated using morphological analysis, marked nuclear condensation and fragmentation of chromatin, which were observed by Hoechst 33258 staining and DNA… CONTINUE READING


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