Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes.

@article{Hirata2006ApoptoticEO,
  title={Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes.},
  author={Hanako Hirata and Lucas Silveira Machado and Clayton S Okuno and Adriano Brasolin and Guiomar Silva Lopes and Soraya Shoubi Smaili},
  journal={Neuroscience letters},
  year={2006},
  volume={393 2-3},
  pages={136-40}
}
In this study, we investigated agents that increased intracellular calcium levels and their correlation with apoptotic cell death induction. We used rat astrocytes to investigate the increase in cytosolic Ca2+ (Ca(c)2+) and apoptosis induction by drugs that mobilize Ca2+ from different sources. We observed that thapsigargin (Thap), caffeine (Caff) and FCCP which caused similar increases in Ca(c)2+ levels (30-40%), also induced similar apoptotic rates (30-35%). On the other hand, antimycin (Anti… CONTINUE READING

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EthanolNo subtypeCaffeine
Apoptotic effect of ethanol is potentiated by caffeine - induced calcium release in rat astrocytes .
CaffeineNo subtypeEthanol
Apoptotic effect of ethanol is potentiated by caffeine - induced calcium release in rat astrocytes .
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