Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells.

@article{Kushwah2009ApoptoticDC,
  title={Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells.},
  author={Rahul Kushwah and Jordan R. Oliver and Jinyi Zhang and Katherine Anne Siminovitch and Jim Hu},
  journal={Journal of immunology},
  year={2009},
  volume={183 11},
  pages={7104-18}
}
Dendritic cell (DC) apoptosis has been shown to play a role in maintaining a balance between tolerance and immunity. However, the mechanisms of how DC apoptosis affects the immune response are unclear. We have shown that in vitro culture of apoptotic DCs with immature DCs, results in their uptake by immature DCs, which subsequently turn into tolerogenic DCs, which then secrete TGF-beta1 and induce Foxp3(+) regulatory T cells (T(regs)). In this study we looked at the effects of apoptotic DCs in… CONTINUE READING

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