Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G

@article{Singh2004ApoptoticDO,
  title={Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G},
  author={Indrapal N. Singh and Robin J. Goody and Celeste Dean and Nael M. Ahmad and Sarah E. Lutz and Pamela E Knapp and Avindra Nath and Kurt F Hauser},
  journal={Journal of NeuroVirology},
  year={2004},
  volume={10},
  pages={141-151}
}
Human immunodeficiency virus-1 (HIV-1) infection affects the striatum, resulting in gliosis and neuronal losses. To determine whether HIV-1 proteins induce striatal neurotoxicity through an apoptotic mechanism, mouse striatal neurons isolated on embryonic day 15 and the effects of HIV-1 Tat1–72 and gp120 on survival were assessed in vitro. Mitochondrial release of cytochrome c, caspase-3 activation, and neuron survival, as well as an alternative apoptotic pathway involving endonuclease G (endo… CONTINUE READING