Apoptotic death induces Abeta production and fibril formation to a much larger extent than necrotic-like death in CGNs.

@article{Cicconi2007ApoptoticDI,
  title={Apoptotic death induces Abeta production and fibril formation to a much larger extent than necrotic-like death in CGNs.},
  author={Simona Cicconi and Antonietta Gentile and Maria Teresa Ciotti and Tiziana Parasassi and Annalucia Serafino and Pietro Calissano},
  journal={Journal of Alzheimer's disease : JAD},
  year={2007},
  volume={12 3},
  pages={211-20}
}
In this study we report that apoptotic death of primary cultures of cerebellar granule neurons is accompanied by release of thioflavin-binding proteins - indicative of the presence of beta-sheet structures - and fibril formation in the culture medium. When the same neurons are subjected to an excytotoxic death caused by 100 microM glutamate exposure, the amount of thioflavin binding is markedly reduced. Western blot analysis shows that fibrils contain monomers, dimers and trimers of amyloid… CONTINUE READING
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