Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

  title={Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.},
  author={Noelia A-Gonz{\'a}lez and Steven J. Bensinger and Cynthia Hong and Susana Beceiro and Michelle N. Bradley and Noam Zelcer and Jos{\'e} Manuel Deniz and Cristina Ram{\'i}rez and Mercedes Gonz{\'a}lez D{\'i}az and German Gutierrez Gallardo and Carlos Ruiz de Galarreta and Jon V. Salazar and F. Guerrero L{\'o}pez and Peter Edwards and John Parks and Miguel And{\'u}jar and Peter Tontonoz and A. Hern{\'a}ndez Castrillo},
  volume={31 2},
Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and respond to apoptotic cells are poorly defined. We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance. Apoptotic cell engulfment activated LXR and thereby induced the expression of Mer, a receptor tyrosine kinase critical for phagocytosis. LXR-deficient… CONTINUE READING
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