Apoptotic cells activate AMP-activated protein kinase (AMPK) and inhibit epithelial cell growth without change in intracellular energy stores.

@article{Patel2015ApoptoticCA,
  title={Apoptotic cells activate AMP-activated protein kinase (AMPK) and inhibit epithelial cell growth without change in intracellular energy stores.},
  author={Vimal A. Patel and Donald Massenburg and Snezana Vujicic and Lanfei Feng and Meiyi Tang and Natalia O. Litbarg and Angelika Antoni and Joyce Rauch and Wilfred Lieberthal and Jerrold S. Levine},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 37},
  pages={22352-69}
}
Apoptosis plays an indispensable role in the maintenance and development of tissues. We have shown that receptor-mediated recognition of apoptotic target cells by viable kidney proximal tubular epithelial cells (PTECs) inhibits the proliferation and survival of PTECs. Here, we examined the effect of apoptotic targets on PTEC cell growth (cell size during G1 phase of the cell cycle). Using a cell culture model, we show that apoptotic cells potently activate AMP-activated protein kinase (AMPK), a… CONTINUE READING