Apoptotic and proliferative markers in chordomas: a study of 26 tumors.

@article{Kilgore2002ApoptoticAP,
  title={Apoptotic and proliferative markers in chordomas: a study of 26 tumors.},
  author={Sony P Kilgore and Richard A. Prayson},
  journal={Annals of diagnostic pathology},
  year={2002},
  volume={6 4},
  pages={222-8}
}
Few studies have examined the role of cell proliferation and apoptotic markers in chordomas. This study retrospectively reviews the clinicopathologic features of 26 chordomas and examines MIB-1, p53, bcl-2, and cyclin D1 immunoreactivity in these neoplasms. Patients ranged in age from 34 to 78 years (mean, 60.7 years) and included 14 females. The most common presentations included lower back pain (N = 15) and headaches (N = 10). Sixteen tumors arose in the lumbosacral region and 10 in the… CONTINUE READING
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