Corpus ID: 9248989

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

  title={Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.},
  author={Jan Kajstura and Weili Cheng and Krzysztof Reiss and William A. Clark and Edmund H. Sonnenblick and S. Krajewski and John Calvin Reed and Giorgio Olivetti and Piero Anversa},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={74 1},
Programmed cell death in the myocardium has been linked to ischemia reperfusion injury as well as to excessive mechanical forces associated with increases in ventricular loading. Moreover, hypoxia activates the suicide program of cardiac myocytes in vitro. Because the supplied portion of the ventricular wall is ischemic and subjected to high levels of systolic and diastolic stresses (acutely after coronary artery occlusion), apoptosis and necrosis may contribute independently to myocyte cell… Expand
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