Apoptotic and Anti-Metastatic Effect of Organotin Coordination Polymer onHuman Hepatocellular Carcinoma (Hepg2) Cells via Intrinsic Pathway ofApoptosis

  title={Apoptotic and Anti-Metastatic Effect of Organotin Coordination Polymer onHuman Hepatocellular Carcinoma (Hepg2) Cells via Intrinsic Pathway ofApoptosis},
  author={Mohammad Ibrahim Alallah and Noura M. Darwish and Mohamed Soliman Elshikh and M Ajmal Ali},
Objective: Dysregulated activation of cellular signaling pathways was shown to be involved in hepatocellular carcinoma (HCC) progression This study focused on the investigation of the anticarcinogen activity of a tin (I) 3-Dsupramolecular coordination polymer (OSCP), a novel organotin supramolecular coordination polymers (SCP namely, 3∞[Ph3SnCu(CN)2.(3-mpy)2] 3∞[Ph3SnCu(CN)2. (3-mpy)2] on HepG2. Design and Methods:This inhibitory effect was confirmed by cell proliferation assay, cell… 

Figures and Tables from this paper

An organotin indomethacin derivative inhibits cancer cell proliferation and synergizes the antiproliferative effects of lapatinib in breast cancer cells.

The results suggest that the use of OID alone or in combination with tyrosine kinase inhibitors could be considered as adjuvants in the treatment of cancer.

Anticancer effect of calycopterin via PI3K/Akt and MAPK signaling pathways, ROS-mediated pathway and mitochondrial dysfunction in hepatoblastoma cancer (HepG2) cells

This study found that calycopterin-treated HepG2 cells were killed off by apoptosis in a dose-dependent manner within 24 h, and was characterized by the appearance of nuclear shrinkage, cleavage of poly (ADP-ribose) polymerase and DNA fragmentation.

In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(iv) complex.

This study assessed the anti-tumor activity of the cyclic trinuclear organotin(iv) complex with an aromatic oximehydroxamic acid group - MG85 - and provided further characterization of its biological targets and evaluated in vivo tumor reduction efficiency using mouse colorectal carcinoma xenografts.

Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax.

Results elucidate a borax-induced apoptotic pathway in HepG2 cells that involves the upregulation of p53 and Bax and the downregulation of Bcl-2.

Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells

Potential cytotoxic effects of compound C1 against human breast cancer MCF-7 cells are revealed and Morphological changes of necrosis and early and late apoptosis stages were observed in treated cells after staining with acridine orange/propidium iodide.

Cytotoxic effect of organotin(IV) benzylisopropyldithiocarbamate compounds on Chang liver cell and hepatocarcinoma HepG2 cell.

Organotin (IV) benzylisopropyldithiocarbamate with insertion of dibutyl and triphenyl functional group possess potent cytotoxicity properties and can be classified as non-toxic.

Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro

Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and it is indicated that TQ could be a promising agent for the treatment of leukemia.

Peroxisome proliferator-activated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines.

TZD PPar gamma ligands showed potent inhibitory effect on proliferation, and could induce apoptosis in RCC cells, suggesting that ligands for PPAR gamma have potential antitumor effects on renal carcinoma cells.

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.

It is shown here that cytosolic p120-catenin (p120) regulates tumor growth upon loss of E-cadherin through the induction of anoikis resistance, and this insight may have clinical implications for the development of tailor-made intervention strategies to better treat invasive and metastatic lobular breast cancer.

Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18.

The effects of TZD18, a novel dual ligand specific for peroxisome proliferator-activated receptor alpha and gamma (PPARalpha/gamma) on Ph(+) lymphocytic leukemia cell lines BV173, SD1, and SupB-15 are reported.