Apoptotic activity of REAPER is distinct from signaling by the tumor necrosis factor receptor 1 death domain.

REAPER (RPR) is a 65-amino acid protein that is critical activator of programmed cell death in Drosophila. On the basis of sequence alignment data, it was recently proposed that RPR might represent an ancestral molecule from which the death domain in a number of proteins may have evolved. We tested this idea by examining the activity of mutations in RPR… CONTINUE READING