Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

  title={Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones},
  author={D. S. Campbell and C. Holt},
  • D. S. Campbell, C. Holt
  • Published 2003
  • Biology, Medicine
  • Neuron
  • Previous work has shown that guidance cues trigger rapid changes in protein dynamics in retinal growth cones: netrin-1 stimulates both protein synthesis and degradation, while Sema3A elicits synthesis, and LPA induces degradation. What signaling pathways are involved? Our studies confirm that p42/44 MAPK mediates netrin-1 responses and further show that inhibiting its activity blocks cue-induced protein synthesis. Unexpectedly, p38 MAPK is also activated by netrin-1 in retinal growth cones and… CONTINUE READING

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