Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones

@article{Campbell2003ApoptoticPA,
  title={Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones},
  author={Douglas S. Campbell and Christine E Holt},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={939-952}
}
Previous work has shown that guidance cues trigger rapid changes in protein dynamics in retinal growth cones: netrin-1 stimulates both protein synthesis and degradation, while Sema3A elicits synthesis, and LPA induces degradation. What signaling pathways are involved? Our studies confirm that p42/44 MAPK mediates netrin-1 responses and further show that inhibiting its activity blocks cue-induced protein synthesis. Unexpectedly, p38 MAPK is also activated by netrin-1 in retinal growth cones and… CONTINUE READING
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The extracellular factor 1 inhibits apoptosis using the phosphatidylinositol 3 -kinase

  • T. P. Herbert, A. R. Tee, C. G. Proud
  • 2002
Highly Influential
4 Excerpts

Retinal axons the ubiquitin-proteasome pathway in regulating abundance

  • W. A. Harris, C. E. Holt, F. Bonhoeffer
  • 1987
Highly Influential
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tectum of Xenopus embryos : a time - lapse video study of single fibres in vivo

  • M. S. Park, M. De Leon, P. Devarajan
  • Development
  • 2002
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1 Excerpt

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