Apoptotic Killing of HIV-1–Infected Macrophages Is Subverted by the Viral Envelope Glycoprotein

@article{Swingler2007ApoptoticKO,
  title={Apoptotic Killing of HIV-1–Infected Macrophages Is Subverted by the Viral Envelope Glycoprotein},
  author={Simon Swingler and Angela M Mann and Jin Zhou and Catherine Swingler and Mario Stevenson},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={97 - 120}
}
Viruses have evolved strategies to protect infected cells from apoptotic clearance. We present evidence that HIV-1 possesses a mechanism to protect infected macrophages from the apoptotic effects of the death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand). In HIV-1-infected macrophages, the viral envelope protein induced macrophage colony-stimulating factor (M-CSF). This pro-survival cytokine downregulated the TRAIL receptor TRAIL-R1/DR4 and upregulated the anti… CONTINUE READING

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