Corpus ID: 47012188

Apoptotic Effect of Capsaicin on Colon Cancer ( Caco-2 ) Cells via Bcl-2 , P 53 and Caspase-3 Pathways

  title={Apoptotic Effect of Capsaicin on Colon Cancer ( Caco-2 ) Cells via Bcl-2 , P 53 and Caspase-3 Pathways},
  author={Entissar S. Al-Suhaibani and Nermin A. El-Morshedi},
Capsaicin (8-methyl-N-vanillyl-6-nonenamide), possesses anti-proliferative properties that can be used as anticancer intervention as promising cancer chemo-preventive constituent. We investigated capsaicin inhibitory activity against colon cancer (Caco-2) cells viability or proliferation. Cells were incubated with capsaicin at concentrations, 300μM/L, 500μM/L, 700μM/L and 900μM/L for 72h at 37°C and 5%CO2. Capsaicin induced Caco-2 cell death in a dose-dependent manner. Capsaicin-treated cells… Expand

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