Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment

@article{Ham2012ApoptoticCA,
  title={Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment},
  author={Tjakko J. van Ham and David Kokel and Randall T. Peterson},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={830-836}
}
Apoptotic cell death is essential for development and tissue homeostasis. Failure to clear apoptotic cells can ultimately cause inflammation and autoimmunity. Apoptosis has primarily been studied by staining of fixed tissue sections, and a clear understanding of the behavior of apoptotic cells in living tissue has been elusive. Here, we use a newly developed technique to track apoptotic cells in real time as they emerge and are cleared from the zebrafish brain. We find that apoptotic cells are… CONTINUE READING
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