Apoptosome structure, assembly, and procaspase activation.

@article{Yuan2013ApoptosomeSA,
  title={Apoptosome structure, assembly, and procaspase activation.},
  author={Shujun Yuan and Christopher W Akey},
  journal={Structure},
  year={2013},
  volume={21 4},
  pages={501-15}
}
Apaf-1-like molecules assemble into a ring-like platform known as the apoptosome. This cell death platform then activates procaspases in the intrinsic cell death pathway. In this review, crystal structures of Apaf-1 monomers and CED-4 dimers have been combined with apoptosome structures to provide insights into the assembly of cell death platforms in humans, nematodes, and flies. In humans, the caspase recognition domains (CARDs) of procaspase-9 and Apaf-1 interact with each other to form a… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 101 references

The Fas–FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

Nature Structural &Molecular Biology • 2010
View 20 Excerpts
Highly Influenced

caspase-3 by XIAP

S. J. Riedl, W. Li, Y. Chao, R. Schwarzenbacher, Y. Shi
Nature • 2005
View 15 Excerpts
Highly Influenced

Dimer formation drives the activation of the cell death protease caspase 9.

Proceedings of the National Academy of Sciences of the United States of America • 2001
View 6 Excerpts
Highly Influenced

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