Apoptosome dysfunction in human cancer

@article{Hajra2004ApoptosomeDI,
  title={Apoptosome dysfunction in human cancer},
  author={Karen M. Hajra and J. Rebecca Liu},
  journal={Apoptosis},
  year={2004},
  volume={9},
  pages={691-704}
}
Apoptosis is a cell suicide mechanism that enables organisms to control cell number and eliminate cells that threaten survival. The apoptotic cascade can be triggered through two major pathways. Extracellular signals such as members of the tumor necrosis factor (TNF) family can activate the receptor-mediated extrinsic pathway. Alternatively, stress signals such as DNA damage, hypoxia, and loss of survival signals may trigger the mitochondrial intrinsic pathway. In the latter, mitochondrial… CONTINUE READING
99 Citations
147 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 99 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 147 references

Overexpression of hepatic prothymosin 702 Apoptosis

  • CG Wu, NA Habib, RR Mitry, PH Reitsma, SJ van Deventer, RA. Chamuleau
  • Br J Cancer
  • 2004

Perifosine, a novel alkylphospholipid, inhibits Apoptosis

  • SB Kondapaka, SS Singh, GP Dasmahapatra, EA Sausville, KK. Roy
  • K. M. Hajra and J. R. Liu protein kinase B…
  • 2004

Similar Papers

Loading similar papers…