Apoptosome dysfunction in human cancer

  title={Apoptosome dysfunction in human cancer},
  author={Karen M. Hajra and J. Rebecca Liu},
Apoptosis is a cell suicide mechanism that enables organisms to control cell number and eliminate cells that threaten survival. The apoptotic cascade can be triggered through two major pathways. Extracellular signals such as members of the tumor necrosis factor (TNF) family can activate the receptor-mediated extrinsic pathway. Alternatively, stress signals such as DNA damage, hypoxia, and loss of survival signals may trigger the mitochondrial intrinsic pathway. In the latter, mitochondrial… CONTINUE READING
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